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GRANULOCYTE COLONY-STIMULATING FACTOR
Descriptors Found:
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DeCS
Descriptor
English
:
Granulocyte Colony-Stimulating Factor
Descriptor
Spanish
:
Factor Estimulante de Colonias de Granulocitos
Descriptor
Portuguese
:
Fator Estimulador de Colônias de Granulócitos
Synonyms
English
:
G-CSF
Tree Number:
D12.644.276.374.410.240.350
D12.776.395.240.200
D12.776.467.374.410.240.350
D23.529.374.410.240.350
Definition
English
:
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the
survival
, proliferation, and differentiation of neutrophilic
granulocyte precursor cells
and functionally activates mature blood
neutrophils
. Among the
family
of
colony-stimulating factors
, G-CSF is the most potent inducer of terminal differentiation to
granulocytes
and
macrophages
of leukemic myeloid cell lines.
Indexing Annotation
English
:
DF: GCSF
See Related
English
:
Receptors, Granulocyte Colony-Stimulating Factor
History Note
English
:
91
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
28968
Unique Identifier:
D016179
Occurrence in VHL
:
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DeCS
CID-10
SciELO
LILACS
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